Haematologic Profile of Haemoglobin Constant Spring and Its Co-inheritance With Alpha and Beta Thalassaemia Among Form Four Students in Negeri Sembilan

Introduction: In Malaysia, the commonest non-deletional alpha (α) thalassaemia is Haemoglobin Constant Spring (Hb CS) which occurs due to a mutation at termination codon of α2 globin gene (TAA>CAA). Presence an abnormal peak Zone 2 on CE or presence small c-window HPLC can be suggestive Hb CS. The objective this study was determine proportion form four students diagnosed with CS and haematologic profile its co-inheritance α beta (β) thalassaemia. Methods: This cross-sectional carried out Hospital Tuanku Ja’afar Seremban (HTJS), involving 15-16 year old secondary school screened for β calculated correlation between full blood count (FBC) parameters results were determined. Results: A total 3121 have 3.24%. had significantly lower mean corpuscular volume (MCV) compared without co-inheritance, t(2)=4.16, p=0.02. also has shown that haemoglobin (MCH) in t(2)=9.89, p<0.01. Conclusion: combination both, FBC analysis used screening making presumed diagnosis